Recent structural studies of these two noncanonical kinases have provided unprecedented insights into their activation mechanisms, enabling us to understand how the third subunit coordinates the T-loop stabilization and enhances kinase activity. In both cases, binding to their respective cyclin partners results in only partial activity, while their full activation requires the presence of an additional subunit. While the classical two-step activation mechanism is generally applicable to cell cycle-related CDKs, both CDK7 and CDK8, involved in transcriptional regulation, adopt distinct mechanisms for kinase activation. The Cyclin-dependent kinases (CDKs) play crucial roles in a range of essential cellular processes. 2MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States. 1Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.Tao Li 1 Hui-Chi Tang 1 Kuang-Lei Tsai 1,2*
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